… speculate that early opioid administration might actually produce an undesirable extension
of the time course of persistent pain. We suggest that the formalin test is not an appropriate …

… for paw edema was observed with 5% formalin using paw … , but it did delay the onset
and/or termination of these re- … and capsazepine antinociceptive effect in formalin and capsa- …

… ASA does not have any delay of onset of its action in the early … are required to induce
antinociception in the formalin test in … oedema in rats in doses with antinociceptive effects [19,53]. …

… the first phase, but both eliminate or strongly reduce the … antagonists is delayed until 5
minutes after formalin injection, … In our study, the magnitude of paw edema was assessed by …

… and underlie the differences in antinociceptive potency … prior to testing) on formalin-induced
behavior and paw edema were … delay (15-45 s), guinea pigs responded violently to formalin …

… and pain-related behaviors with a delayed recession after the … EB-stained skin also appeared
swollen. N = 4 experiments (2 … magnitude of the second phase compared to the first phase …

… used formalin test to screen antinociceptive drug candidates is … In addition, immediate paw
swelling, plasma extravasation … transient antinociceptive opioid effect but occurred delayed at …

… at the earlier time interval may be a delayed manifestation of … It is thus likely that the
magnitude of the afferent activity is … study, paw oedema at 60 min following formalin injection was …

… to determine the stimulus intensity threshold stiffness required … of microglia followed by a
delayed astrocytic activation (as … Antinociceptive effects of systemic paeoniflorin on bee venom…

… Hyperalgesia and edema are present for approximately 1 to … The first phase of the perioral
formalin test lasts only about 1 … The CFA results in a delayed hypersensitivity reaction with …